Weege taught art at the University of Wisconsin.
William Weege worked predominantly with silkscreen because of its immediacy and directness. He created the "print production" area in response to emerging photo-based technologies for printmakers. He was particularly interested in adapting graphic arts techniques for fine arts applications. He was a leader in the development of digital printmaking.
Best known for his large abstract handmade paper projects, Weege most often produced work for corporate commissions, as well as for embassies around the world. His art can be seen at the Prudential Building in Minneapolis, the Renaissance Center in Detroit, Honda Headquarters in Tennessee, and in embassies in Finland, Germany, and Chile.
Weege’s work is in many museum collections, including the Brooklyn Museum, New York, the Museum of Modern Art, New York, The Philadelphia Museum of Art, Pennsylvania, the Detroit Museum of Art, and the San Francisco Museum of Art, California. In 1991 and 1992 he participated in a collaborative project, the Arts America Project Grant, exhibited in Finland and Korea. Weege collaborated for over 50 years with the American abstract painter Gillliam, as well as working with painter Alan Shields. William Weege was founder and artistic director of Tandem Press. The Tandem Press grew from Weege's love of artistic collaboration.
An early practitioner of the 1960s handmade paper revival, Weege was highly regarded for his broad understanding of all aspects of printmaking. Weege constantly developed new techniques. His enthusiasm and exuberance were infectious and when asked to describe his philosophy for art, he said, "Do it."
