His first solo exhibition was at the Galerie Craven in Paris in 1953, entitled Peintures en Mouvement (Paintings in movement), where he showed two series of early work. In one, grids of painted strips that incorporated different designs on opposite sides created images that merged and changed as spectators shifted their viewing position (a type of lenticular print that eventually became known as an Agamograph). In the other, his Transformable Pictures (Images transformables, 1953–61), viewers could manually activate works and rearrange their visual elements. While not the first Optical-Kinetic artist, Agam encouraged spectator participation at a time when such strategies were rare.
Agam produced many public commissions, including a moving salon environment at the Elysée Palace in Paris in 1972. In the space, walls were covered with lenticular imagery; transparent doors were included; and a sculpture was placed on a kinetic carpet. In all, the environment shifted according to the viewer's position. He continued to produce abstract, kinetic work that incorporated light, sound, and viewer participation.