Helen Frederick is known mainly for hand-driven media such as custom-formed paper, artist books, paintings, drawings, and prints that often incorporate the use of language. Frederick's work is included in the Whitney Museum of American Art, the National Gallery of Art, the Library of Congress, and the Smithsonian American Art Museum, DC and many other national and international collections. Major exhibitions of Frederick's work have been held at The Phillips Collection, Eleanor D. Wilson Museum at Hollins University, VA, Dieu Donne' Gallery, NY, Henie-Onstad Museum, Norway, and in traveling museum exhibitions in Japan, Scandinavia, Europe, Greece, The United States and South America. As an advocate for and active participant in the Washington DC metropolitan area art scene for the last forty years, she has served on the directorial boards of various local and national organizations and national peer review panels. She has exhibited and curated exhibitions and fulfilled speaking engagements around the world, always emphasizing collaboration across disciplines.