She worked as an educator, beginning in 1970, in the Department of Education at the Cleveland Museum of Art. She has served on the boards of the Cleveland Institute of Art, where she founded the Craft Council; the Museum of Contemporary Art Cleveland (MOCA); the Print Club of Cleveland and the Contemporary Art Society of the Cleveland Museum of Art; and Contemporary Forum, Phoenix Art Museum. In January, 2020 she became a member of the board of trustees of the Heard Museum in Phoenix, Arizona.
In 1988 she created the art collection at University Hospitals in Cleveland and served as founding curator until her retirement in 2011. She is the author of the book, Artwork From the Collection of University Hospitals. In 1998 the Cleveland Artist Foundation honored her for her contribution to the visual arts in Cleveland, and in 2010 she was awarded the coveted Cleveland Arts Prize. In 2017 the rotating art gallery at the main campus of University Hospitals was renamed the Trudy Wiesenberger Gallery.
