During her career Otis exhibited work throughout the United States. She was a member of the Philadelphia Water Color Club, the Pennsylvania Society of Miniature Painters, and The Plastic Club, and was a sister of Kappa Kappa Gamma.[3] Among her pupils at Wheaton was the future Precisionist Molly Luce.[9]
Otis was the aunt of painter Elizabeth Otis Dunn and illustrator Samuel Davis Otis,[4] and was a descendant of Mayflower passenger John Howland;[3] numerous other ancestors were prominent in the history of Scituate, Massachusetts.[1] A lecture series at Wheaton was established in her honor[10] by the Class of 1931 after her death.[5] A miniature watercolor-on-ivory portrait of Dorothy Gifford, titled A College Girl, is currently owned by the Philadelphia Museum of Art.[11]