In 2017, she was commissioned by the Solomon R. Guggenheim Museum to create A talking parrot, a high school drama class, a Punjabi TV show, the oldest song in the world, a museum artwork, and a congregation's call to action circle through New York, in collaboration with Jon Rubin. Objects from six unique venues in New York City were circulated between sites, creating a network of social and material exchange. In October 2018, Clayton and Jon Rubin debuted the collaborative project Fruit and Other Things at the 57th Edition of the Carnegie International. Clayton's work has been exhibited at the Metropolitan Museum of Art, the Fabric Workshop and Museum in Philadelphia, the Carnegie Museum of Art in Pittsburgh, and Crystal Bridges Museum of American Art in Bentonville, and the Blanton Museum of Art, Austin among other institutions.
Her work is represented in multiple public collections, including the Blanton Museum of Art, Austin, Texas; Carnegie Museum of Art, Pittsburgh, Pennsylvania; the Metropolitan Museum of Art, New York, New York; and the San Francisco Museum of Modern Art, California among others. Clayton has exhibited with Catharine Clark Gallery since 2016 and has been represented by the gallery since 2019.
